• Tohoku J. Exp. Med. · Aug 2022

    Case Reports

    Detection of Secondary Corneal Lactoferrin Amyloidosis Based on Histologic Biopsies Combined with Mass Spectrometry: A Case Report.

    • Hong Tang, Wenhui Liu, Rui Wu, Feifei Zhao, and Min Xie.
    • Department of Pathology, Nanjing Medical University Affiliated Wuxi Second Hospital.
    • Tohoku J. Exp. Med. 2022 Aug 6; 258 (1): 43-48.

    AbstractAmyloidosis is characterized by systemic or local deposition of amyloid fibrils outside organs and tissues. Amyloidosis is rarely seen on cornea. A 30-year-old woman patient had had trichiasis in both eyes for 8 years. Trichiasis was observed, which touched the cornea. Slit lamp microscopy showed white gelatinous droplet-like eminences and trichiasis in the lower cornea of the right eye. Optical coherence tomography showed that the lesion involved most of the cornea. Hematoxylin and eosin staining showed that most of the stroma stained red, with scattered inflammatory cells. High expression of lactoferrin was detected by mass spectrometry, and the case was diagnosed as secondary corneal lactoferrin amyloidosis in the right eye.

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