• Yutaka Tateda, Ryoukichi Ikeda, Risako Kakuta, Junya Ono, Kenji Izuhara, Takenori Ogawa, Kazue Ise, Hiroki Shimada, Keigo Murakami, Kazuhiro Murakami, Yasuhiro Nakamura, Yukio Katori, and Nobuo Ohta.
• Division of Otolaryngology, Tohoku Medical and Pharmaceutical University Hospital.
• Tohoku J. Exp. Med. 2022 Aug 9; 258 (1): 55-62.

AbstractLong-term voice abuse or sudden vocal fold microvascular disruption may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and also in various otolaryngological diseases. The aim of this article was to investigate the expression and the role of periostin in the formation of vocal fold polyps. The expression patterns of periostin in 59 surgical specimens of vocal fold polyps from 54 patients were investigated immunohistochemically. Normal vocal fold mucosa specimens from 5 patients who had undergone total laryngectomy were used as the control group. Retrospective study with planned data collection was conducted at Tohoku Medical and Pharmaceutical University. Expression of periostin was detected in 43 (72.9%) samples and four patterns of periostin expression were observed in vocal fold polyps: negative type, superficial type, infiltrative type, and diffuse type. An association was observed between periostin expression patterns and the histological subtypes of vocal fold polyps. The infiltrative pattern of periostin expression was significantly dominant in vascular-hyaline types. Expression of transforming growth factor-β (TGF-β) was also detected in the vocal fold polyps. Our results confirmed that periostin might be involved in certain pathological changes in vocal fold polyps, such as extracellular matrix accumulation, local fibrosis, and formation and development of vocal fold polyps.

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