• Navid Omidkhoda, Farshad Abedi, Vahid Ghavami, Hossein Rahimi, Sara Samadi, Omid Arasteh, and Amir Hooshang Mohammadpour.
• Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 22267612226761.

MethodsThe databases of PubMed, Scopus, Embase, and Web of Science were searched systematically up to November 2021. The quality of RCTs was assessed by Cochrane Collaboration's tool and the risk of bias was assessed for cohort studies through NOS score.ResultsOut of 3288 articles, eight studies were eligible to be included in this study. Our review retrieved six RCTs and two retrospective cohort studies consisting of 950 participants diagnosed by DIC. A significant effect of heparin on DIC mortality was identified in four studies. Furthermore, heparin was used as a control group in three studies.ConclusionsWe concluded that administration of heparin and its preparations in DIC patients could reduce the mortality rate and duration of hospitalization, especially in the earlier stages of DIC.Copyright © 2022 Navid Omidkhoda et al.

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