• Yanhua Huang, Zuoteng Wang, Bing Zhao, Yahui Ma, Yanan Ou, Hao Hu, Xiaohe Hou, Jintai Yu, and Lan Tan.
• Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong 266071, China.
• Chin. Med. J. 2022 Jun 20; 135 (12): 1425-1431.

BackgroundPrevious studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.MethodsA total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke.ResultsMultivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants ( P  < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278-2.275, P  < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group ( P  < 0.001), but not in the mid-life group ( P  = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P  < 0.001; non-stroke group, P  = 0.027).ConclusionsAn elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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