• Shih-Wei Yang, Yu-Jen Lin, Yung-Wen Cheng, Yuan-Yuei Chen, and Wei-Liang Chen.
• Division of Plastic and Reconstruction Surgery, Department of Surgery, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
• Pol. Arch. Med. Wewn. 2022 Oct 21; 132 (10).

IntroductionTrabecular bone score (TBS) is a novel way for clinicians to evaluate bone quality. It is directly associated with the mechanical strength of bones and helps predict fractures. Vitamin D, a secosteroid that enhances calcium absorption, is commonly used to strengthen the skeletal system.ObjectivesThe present analysis aimed to determine the relationship between vitamin D levels and TBS by analyzing data from the National Health and Nutrition Examination Survey.Patients And MethodsA total of 4464 persons (2148 men and 2316 women) were included in our study. The participants were analyzed according to sex, obesity status, and T‑score using regression models.ResultsWe noted a remarkably positive relationship between serum levels of 25‑hydroxyvitamin D (25[OH]D) and TBS after the results were fully adjusted (β = 0.319; 95% CI, 0.145-0.494; P <0.001). T‑score analysis showed that serum 25(OH)D levels were related to TBS in the group of participants with normal bone mineral density (T‑score >-1) (β = 0.311; 95% CI, 0.097-0.525; P = 0.005). However, in the osteopenia (T‑score between -1 and -2.5) and osteoporosis (T‑score <-2.5) group there was no such association (P >0.05).ConclusionsOur study shows that low serum levels of 25(OH)D may decrease the TBS, which represents the skeletal microarchitecture and is a fracture risk factor in individuals with normal T‑scores.

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