• Fatma M El-Senosy, Rasha Elsayed Mohamed Abd El Aziz, Sammar Ahmed Kasim, Lamia Abdulbary Gad, Donia Ahmed Hassan, Seham Sabry, Ismail Mohamed El Mancy, Taiseer Ahmed Shawky, Ibrahim Ghounim Ramadan Mohamed, Rady Elmonier, Essam Kotb, and Abeer Mohammed Abdul-Mohymen.
• Department of Internal Medicine, Faculty of Medicine (Girls) Al-Azhar University, Cairo, Egypt.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 4524637.

ResultsHD and CKD groups had significantly higher endocan levels when compared with control group (median (IQR): 519.0 (202.3-742.0) versus 409.0 (245.3-505.3) and 273.0 (168.0-395.5) ng/L, respectively). Also, HD patients had significantly higher endocan levels when compared with CKD levels. HD patients had significantly higher carotid intima-media thickness (CIMT) when compared with CKD patients (median (IQR): 0.80 (0.80-0.90) versus 0.75 (0.73-0.75) mm, p < 0.001). HD patients had significantly higher frequency of SCA when compared with CKD patients (46.7% versus 13.3%, p=0.005). Patients with SCA had significantly higher hsCRP (median (IQR): 36.5 (26.8-43.5) versus 24.0 (15.8-29.0) mg/dl) and endocan levels (697.0 (528.3-974.8) versus 222.5 (158.8-565.8) ng/L) when compared with patients without SCA. ROC curve analysis of endocan for identification of SCA in HD patients showed that at a cutoff of 380.5 ng/L, endocan has an AUC of 0.862 with a sensitivity and specificity of 92.9% and 68.7%, respectively.ConclusionsSerum endocan levels are related to SCA in HD patients. In addition, it is associated with the hyperinflammatory state in those patients.Copyright © 2022 Fatma M. El-Senosy et al.

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