• Nutrition · Nov 2022

    Time-restricted feeding during embryonic development leads to metabolic dysfunction in adult rat offspring.

    • Kelly Valério Prates, Audrei Pavanello, Adriane Barreto Gongora, Veridiana Mota Moreira, Ana Maria Praxedes de Moraes, Kesia Palma Rigo, Elaine Vieira, and MathiasPaulo Cezar de FreitasPCFLaboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Parana, Brazil..
    • Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Parana, Brazil. Electronic address: kvp.86@hotmail.com.
    • Nutrition. 2022 Nov 1; 103-104: 111776.

    ObjectivesMaternal circadian eating time and frequency are associated with altered glucose metabolism during pregnancy in humans. Research on long maternal fasting intervals is inconclusive, and little is known about the effect of maternal time feeding on offspring health. Therefore, the aim of the present study is to determine whether maternal time feeding influences the metabolic status of both male and female offspring.MethodsPregnant rats were provided ad libitum access to chow diet or fed during either the light phase (LP) or dark phase (DP) during embryonic development. At the age of 150 days, glucose tolerance, lipid concentrations, and insulin secretion were determined in adult male and female offspring.ResultsBoth male and female offspring of LP and DP dams exhibited alterations in the lipid profile, and female offspring were glucose intolerant. Glucose-stimulated insulin secretion decreased in male and female offspring of LP and DP dams. Acetylcholine increased insulin secretion in male and female offspring. Islets from male and female offspring of DP dams exhibited less pronounced inhibition of insulin secretion by epinephrine, suggesting alterations in the cholinergic and adrenergic pathways in these animals.ConclusionsOur data suggest that a time-restricted feeding regimen during embryonic development could program rat offspring for metabolic dysfunction during adulthood.Copyright © 2022 Elsevier Inc. All rights reserved.

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