• Li Zhang, Lijuan Qiao, Minghua Zhang, Ya'e Xue, Xueting Zhang, and Xiang Gao.
• Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Gansu, China.
• Medicine (Baltimore). 2022 Aug 19; 101 (33): e27915e27915.

BackgroundColorectal cancer is a malignant tumor second only to lung and breast cancer in the West. The liver is the main target organ for colorectal cancer metastasis, affecting the prognosis and survival. Surgical treatment has made great progress in colorectal cancer liver metastasis , including radiofrequency ablation (RFA), high-intensity focused ultrasound (HIFU) ablation.ObjectClinical treatments for colorectal cancer liver metastases are not the same. In order to clarify the impact of surgical resection, RFA and HIFU, we provided a decision-making basis for the clinical treatment of colon cancer liver metastasis through systematic reviews and network meta-analysis (NMA).MethodsWe systematically searched the Chinese and English databases: PubMed, Embase, CENTRAL, CINAHL, Web of Science, CNKI, CBM, VIP, Wan Fang. Literature screening, data extraction, and quality evaluation were carried out by two researchers, and finally, use Stata to carry out meta-analysis.ResultsThis study is ongoing and the results will be submitted to a peer-reviewed journal for publication.Protocol Registration NumberINPLASY202150044.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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