• Arch Med Sci · Jan 2022

    Heterologous high dose SARS-CoV-2 mRNA vaccine booster may improve immune response in seronegative kidney transplant recipients.

    • Leszek Tylicki, Bogdan Biedunkiewicz, Zuzanna Ślizień, Marta Muchlado, and Alicja Dębska-Ślizień.
    • Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
    • Arch Med Sci. 2022 Jan 1; 18 (4): 1100-1102.

    IntroductionThree-dose mRNA vaccination against COVID-19 is unable to elicit a sufficient immune response in immunocompromised subjects.MethodsThe aim of the study was to conduct a retrospective evaluation of the efficacy of a heterologous mRNA booster with mRNA-1273 in constantly seronegative kidney transplant recipients (KTRs) after three doses of the BNT162b2 mRNA vaccine. Twelve seronegative KTRs received a mRNA-1273 booster 5 months after the third dose of BNT162b2.ResultsA total of 5 out of 12 patients (41.7%) seroconverted, with a mean titer of 353 BAU/ml.ConclusionsThe administration of a heterologous mRNA vaccine as a booster may be an effective alternative for achieving post-vaccination immunity in seronegative KTRs.Copyright: © 2022 Termedia & Banach.

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