• Mohsen Mazidi, Dimitri P Mikhailidis, Abbas Dehghan, Jacek Jóźwiak, Adrian Covic, Naveed Sattar, and Maciej Banach.
• Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Strand, London, UK.
• Arch Med Sci. 2022 Jan 1; 18 (4): 900911900-911.

IntroductionThe reported relationship between coffee intake and renal function is poorly understood. By applying two-sample Mendelian randomization (MR) and systematic review and meta-analysis we investigated the association of caffeine and coffee intake with prevalent CKD and markers of renal function.Material And MethodsFor the individual data analysis we analyzed the National Health and Nutrition Examination Surveys (NHANES) data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever genome-wide association studies (GWAS) conducted on coffee intake (N = 91,462) and kidney function (N = 133,413). The inverse variance weighted method (IVW), weighted median-based method, MR-Egger, MR-RAPS, and MR-PRESSO were applied. Random effects models and generic inverse variance methods were used to synthesize quantitative and pooled data for the meta-analysis, followed by a leave-one-out method for sensitivity analysis.ResultsFinally, we included the data of 18,436 participants; 6.9% had prevalent CKD (based on eGFR). Caffeine intake for the general population was 131.1 ±1.1 mg. The percentage of participants with CKD, by caffeine quartile, was 16.6% in the first (lowest) quartile, 13.9% in the second, 12.2% in the third and 11.0% in the top quartile (p < 0.001). After adjustment, for increasing quartiles for caffeine consumption, mean urine albumin, albumin-creatinine ratio and estimated glomerular filtration rate (GFR) did not change significantly (p > 0.234). In fully adjusted logistic regression models, there was no significant difference in chances of CKD prevalence (p-trend = 0.745). In the same line, the results of MR showed no impact of coffee intake on CKD (IVW: β = -0.0191, SE = 0.069, p = 0.781) or on eGFR (overall = IVW: β = -0.0005, SE = 0.005, p = 0.926) either in diabetic (IVW: β = -0.006, SE = 0.009, p = 0.478) or non-diabetic patients (IVW: β = -6.772, SE = 0.006, p = 0.991). Results from the meta-analysis indicated that coffee consumption was not significantly associated with CKD (OR = 0.85, 95% CI: 0.71-1.02, p = 0.090, n = 6 studies, I 2 = 0.32). These findings were robust in sensitivity analyses.ConclusionsImplementing different strategies, we detected no significant association between coffee consumption and renal function or risk of CKD.Copyright: © 2022 Termedia & Banach.

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