• Yue Zhou and Liang-da Li.
• Department of Neurology, The People's Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang Province, China.
• Medicine (Baltimore). 2022 Aug 26; 101 (34): e30168.

BackgroundThis systematic review evaluates the effect of exercise training in the treatment of patients with mild cognitive impairment (MCI).MethodsPubMed, Medline, EMBASE, Web of Science, and Cochrane Library databases were systematically searched up to Oct 2021 in order to identify randomized controlled trials (RCTs) which evaluated the effects of physical exercise in persons with MCI. Changes of cognitive and physical function were tested using pre- and postMMSE and TUG scores, and were compared with control intervention.ResultsA total of 10 RCTs involving 635 MCI patients were included in the meta-analysis. Physical exercise improved MMSE scores (MD 0.71, 95 % CI 0.57 to 0.85, P < .00001, I2 = 95 %) and TUG performance (MD -0.82, 95 % CI -1.20 to -0.45, P < .00001, I2 = 12 %) in patients with MCI.ConclusionsThis meta-analysis demonstrated a positive effect of exercise training in people with MCI in relation to cognitive and physical function. These findings suggest exercise interventions be persistent, and reveal that more high-quality researches are needed.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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