• Keiichi Ohira, Kenta Konishi, Shuhei Aramaki, Ryo Kokubo, Kouhei Wakabayashi, Masanori Hirata, Michiko Imai, and Katsumasa Nakamura.
• Department of Radiology, Hamamatsu University School of Medicine, Shizuoka, Japan.
• Medicine (Baltimore). 2022 Aug 26; 101 (34): e30343.

IntroductionThromboangiitis obliterans (TAO) is a rare disease of unknown cause that causes segmental vasculitis in peripheral blood vessels. It is uncertain whether its presence causes serious adverse events in patients receiving external beam radiotherapy.Patient ConcernsA 73-year-old Japanese man with prostate cancer underwent external beam radiotherapy.DiagnosisAfter completion of radiotherapy, fingertip pain occurred, leading to the diagnosis of TAO.InterventionsThe patient was instructed to stop smoking, but was unable to do so.OutcomesNine months after the completion of radiotherapy, fecaluria appeared, and a rectourethral fistula was diagnosed by contrast enema. The patient's TAO was poorly controlled, and the patient died from aspiration pneumonia 33 months after completion of the radiotherapy regimen. No tumor recurrence was observed during this process, and there were no risk factors other than TAO that may have formed a rectourethral fistula.LessonsThis is the first report of rectourethral fistula caused by external beam radiotherapy for prostate cancer in which TAO was suspected to be involved. Although little is known about the relationship between TAO and radiotherapy, it should be noted that radiotherapy itself may increase the risk of normal tissue toxicity in patients with TAO.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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