• Florina Rad, Mihaela Stancu, Lucia-Emanuela Andrei, Florentina-Ionela Linca, Mariana BuicăAlexandraA0000-0002-3521-9956"Grigore Alexandrescu" Clinical Emergency Pediatrics Hospital, Bucharest, Romania., Maria-Madalina Leti, Iuliana Dobrescu, Ilinca Mihailescu, and Magdalena Efrim-Budisteanu.
• "Prof. Dr. Alexandru Obregia" Clinical Hospital of Psychiatry, Bucharest, Romania.
• Medicine (Baltimore). 2022 Aug 26; 101 (34): e30288.

AbstractStudies on early onset schizophrenia are limited because of their low prevalence but the reported results stated that early onset is associated with a poorer outcome. The present research analyzed the stability rate of the psychotic-related disorders from childhood to adult life. The study was based on an observational, retrospective, descriptive analysis study. The subjects were selected from patients admitted to the pediatric psychiatry ward of "Alexandru Obregia" Psychiatry Hospital between 2009 and 2018 for a psychosis-related disorder, who were 18 years or older at the moment of data collection and who also had admissions into the adult's psychiatry wards of the hospital. Of the 115 subjects, 93, representing 80.87% of the total, maintained a diagnosis of psychotic spectrum disorder into adulthood. The diagnosis was maintained in 82.4% of cases with onset before 13 years old and 80.6% of cases with onset after the age of 13 years of age. Of the 42 subjects who presented affective symptoms during childhood, 71.43% also presented affective symptoms into adulthood. These findings indicate an important stability rate of psychosis from childhood and adulthood and come in accordance with the theory of overlap between psychotic and affective disorders. The results underline the importance of an accurate diagnosis of early and very early onset schizophrenia (VEOS), the need for early and multimodal intervention, but also the need for long-term management of these patients and continuing research regarding psychotic-related disorders in children and adolescents.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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