• Yuanjun Sun, Xiaohong Yu, Xianjie Xiao, Shiyu Dai, Rongfeng Zhang, Zhongzhen Wang, Chengming Ma, Xiaomeng Yin, Lianjun Gao, Yanzong Yang, and Yunlong Xia.
• Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
• Medicine (Baltimore). 2022 Aug 26; 101 (34): e30277.

RationaleWe reported a case with cardiomyopathy induced by frequent premature ventricular contractions (PVCs) and followed ventricular escape beats (VEBs). PVCs with VEBs in the compensatory pause which induced cardiomyopathy is rarely reported. Also, the case exhibited many characteristics of PVCs which were more likely to induce cardiomyopathy, like the location of origin, the longer coupling interval, and the QRS wave companied with the P wave.Patient ConcernsA 53-year-old man with left ventricular (LV) dysfunction presented with palpation, chest distress, and dyspnea for 3 years. Holter revealed a high burden of ventricular rhythm of PVCs and another wide QRS patterns (96,562 total beats with 87,330 wide QRS beats in 24 hours). The LV ejection fraction decreased to 34% and the left ventricle, right and left atria all dilated.DiagnosisHe was diagnosed with PVC-induced cardiomyopathy.InterventionsThe patient experienced intracardiac electrophysiological examination which revealed frequent PVCs followed by VEBs in the compensatory pause. Activation mapping of the PVCS and ablation were performed.OutcomesPVCs and VEBs disappeared after ablation. The LV ejection fraction increased to 46% at 2 days after the procedure. The diameters of the right and left atria were also significantly reduced.LessonsVEBs may occur during the compensatory pause of PVCs. PVCs with VEBs can lead to a high burden of ventricular rhythm and LV dysfunction. Ablation of the PVCs can also eliminate VEBs and improve the LV function.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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