• Sehun Lim, Kwangrae Cho, Wonjin Lee, Jinhyeok Kim, Jongwook Bang, and Seunghee Ki.
• Department of Anaesthesiology and Pain Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
• J Clin Anesth. 2022 Nov 1; 82: 110945.

Study ObjectiveAlthough the performance of phase lag entropy (PLE), a new depth-of-sedation monitor based on the diversity of temporal patterns in the phase relationships in electroencephalogram (EEG) data, during propofol sedation has been proven through several studies, since different sedatives have different effects on EEG, we aimed to evaluate the performance of the PLE in comparison with the bispectral index (BIS) during dexmedetomidine sedation.DesignA prospective, observational, and non-inferiority trial.SettingTertiary university hospital operating room.PatientsForty-two patients aged 20-80 years who were scheduled to undergo elective surgery under spinal anesthesia and had American Society of Anesthesiologists (ASA) physical status I to III were enrolled in this study.InterventionsDexmedetomidine was administered with a loading dose of 0.5-1 μg/kg for 10 min, followed by a maintenance dose of 0.3-0.6 μg/kg/h.MeasurementsThe depth of sedation was assessed using the modified observer's assessment of alertness/sedation (MOAA/S) scale; the data for PLE and BIS were collected; and vital signs, including blood pressure, heart rate, EKG, and pulse oximetry, were evaluated.Main Results215,082 data points for the MOAA/S score and PLE and BIS values were analyzed. The baseline variabilities of PLE and BIS were 4.53% and 7.02%, respectively. The Spearman correlation coefficients of the MOAA/S score with PLE and BIS were 0.599 and 0.566, respectively. The prediction probabilities of the MOAA/S score with PLE and BIS were 0.647 and 0.636, respectively. When the MOAA/S score was 3 points, the mean (SD) values of PLE and BIS were 68.35 (15.68) and 75.85 (9.81), respectively, However, the mean (SD) values of PLE and BIS for an MOAA/S score of 1 point were 56.08 (12.49) and 68.29 (12.65), respectively.ConclusionsPLE shows potential as a hypnotic depth indicator during dexmedetomidine sedation, and its performance was not inferior to that of BIS.Copyright © 2022 Elsevier Inc. All rights reserved.

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