• Ozgur Komurcu, Burhan Dost, Neslihan Unal Akdemir, and Fatma Ulger.
• Department of Anesthesiology and Reanimation, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
• J Coll Physicians Surg Pak. 2022 Sep 1; 32 (9): 1116-1121.

ObjectiveTo investigate the effect of the fluid challenge test on the optic nerve sheath diameter (ONSD) change.Study DesignQuasi-experimental study.Place And Duration Of StudyDepartment of Anesthesiology and Reanimation, Ondokuz Mayis University Hospital, Samsun, Turkey, from January to November 2021.MethodologyA fluid challenge was defined as a 500 mL crystalloid infusion administered over 10 minutes, and fluid responsiveness was defined as a subsequent increase in stroke volume of at least 15% administered to the ICU patients. The ONSD and hemodynamic variables were measured by ultrasonography before (T0), at the end (T1), and 30 min after the fluid challenge (T2). The primary outcome of the study was the change in ONSD measurements associated with the fluid challenge, and the secondary outcome was the relationship between fluid responsiveness and the change in ONSD.ResultsA total of 60 patients were included. The ONSD (mm) value was significantly higher at T1 compared to T0 (mean ± standard deviation: 5.12±0.30 mm vs. 5.10±0.32 mm; p=0.011). However, at T2, the ONSD was similar to that at T0 (5.10±0.31 mm vs. 5.10±0.32 mm; p=0.662). The stroke volume (mL) was also significantly higher at T1 and T2 compared to T0 [median IQR 60 (6) mL vs. 60 (4.7) mL vs. 52 (5) mL, respectively, p <0.01]. No significant relationship was found between the ONSD and the change in fluid responsiveness (p=0.621).ConclusionThe fluid challenge test increases ONSD and may cause an increase in intracranial pressure.Key WordsFluid therapy, Stroke volume, Intracranial pressure, Ultrasonography, Optic nerve sheath diameter.

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