• Bushra Siddiqui, Shahbaz Habib Faridi, Asfa Shams, and Jowairiah Hassan.
• Department of Pathology, JN Medical College, AMU, Aligarh, Uttar Pradesh, India.
• J Coll Physicians Surg Pak. 2022 Sep 1; 32 (9): 1205-1208.

AbstractLeiomyosarcoma malignant tumours arise from the smooth muscle cells. They are rapidly growing tumours with aggressive behaviour and poor prognosis. Although relatively rare, they pose a diagnostic challenge as they comprise a large spectrum of diagnostic entities. Herein, we describe three cases of leiomyosarcoma developing at unusual sites and posing diagnostic challenges. Our first case is a leiomyosarcoma developing at the post-burn scar site; the second case is of primary pulmonary leiomyosarcoma, and the third is retroperitoneal leiomyosarcoma. Histopathological examination is not sufficient all the time for making the diagnosis of leiomyosarcoma because there is a morphologic overlap with other malignancies. Immunohistochemistry acts as an adjunct to arrive at a definite diagnosis and hence, proves to be the most important ancillary technique in the diagnosis of such tumours. Though these tumours arise most commonly from the uterine smooth muscle, but rarely encountered at unusual sites posing diagnostic difficulties. Key Words: Leiomyosarcoma, Retroperitoneal, Pulmonary, Post-burn scar.

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