• J Coll Physicians Surg Pak · Sep 2022

    Case Reports

    Hearing Loss After the First Low Dose Administration of Cisplatin.

    • Atila Yildirim, Evren Fidan, and Feyyaz Ozdemir.
    • Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
    • J Coll Physicians Surg Pak. 2022 Sep 1; 32 (9): 1216-1218.

    AbstractCisplatin is commonly used antineoplastic drug that is effective against different types of tumours. Nephrotoxicity, neurotoxicity, and ototoxicity constitute the main dose-limiting side effects of the drug. We present a case of sensorineural hearing loss after the first low dose of cisplatin. Five days after receiving an intravenous 30 mg/day at 120 minutes, the patient presented with serious bilateral sensorineural hearing loss. Cisplatin-induced hearing impairment is generally dose-related and cumulative; however, the toxicity can occur after the first dose without a cumulative high-dose and can be irreversible. Key Words: Cisplatin, Hearing Loss, Ototoxicity.

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