• J Coll Physicians Surg Pak · Sep 2022

    Comparison of Low Molecular Weight Heparin Used alone or Combined with Aspirin in the Treatment of Fetal Growth Restriction.

    • Saiqiong He, Lingling Liang, and Sailin He.
    • Department of Obstetrics, Xinchang people's Hospital, Shaoxing, China.
    • J Coll Physicians Surg Pak. 2022 Sep 1; 32 (9): 1228-1229.

    AbstractThe objective of the study was to compare the efficacy of low-molecular weight heparin (LMWH) alone and use in the combination with aspirin in the treatment of fetal growth restriction (FGR) patients. Ninety-six FGR patients were divided into the LMWH group (n=48) and the combined group (n=48), according to the different treatments. This research showed after treatment, values of PI, RI and S/D, serum IL-6 and TNF-α in the combined group were lower than those in the LMWH group (all p <0.001). The frequency of pregnancy complications and adverse neonatal outcomes in the combined group were 2 (4.2%) lower than the LMWH group (p=0.045, 0.025). Combination of LMWH with aspirin in FGR patients effectively reduced levels of IL-6 and TNF-α within the mother, improved fetal developmental parameters, and reduced the frequency of pregnancy complications and adverse neonatal outcomes compared with LMWH treatment alone. Key Words: Fetal growth restriction (FGR), Low-molecular weight heparin (LMWH), Aspirin, Pregnancy, Newborn.

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