• Elham Karimi, Farnaz Shahdadian, Amir Hadi, Mohammad-Aref Tarrahi, and Mohammad Javad Tarrahi.
• Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
• Int. J. Clin. Pract. 2022 Jan 1; 2022: 9622546.

BackgroundThe present systematic review and meta-analysis of randomized controlled trials (RCTs) aimed at determining the effect of saffron supplementation on renal function.MethodsElectronic databases were searched up to February 2021. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool. The overall weighted mean difference (WMD) and their 95% confidence intervals (CIs) were calculated using random-effect models. P < 0.05 was considered statistically significant.ResultsA total of 11 trials were included in this study. Saffron had beneficial effect on BUN (WMD = -0.69 mg/dl; 95% CI, -1.36 to -0.01; P=0.046) compared to placebo, with significant heterogeneity (I 2 = 49.6%, P=0.037). However, it had no significant effect on serum Cr (WMD = 0.04 mg/dl; 95% CI: -0.01 to 0.09; P=0.127).ConclusionIt seems that saffron supplementation had no significant effect on Cr as a renal function factor. However, BUN reduction was significant in the saffron group compared to placebo.Copyright © 2022 Elham Karimi et al.

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