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- A Chiti, G Gialdini, E Terni, N Giannini, M Gennaro, G A Lazzarotti, M Puglioli, G Orlandi, and U Bonuccelli.
- Division of Neurology, Department of Clinical and Experimental Medicine, University of Pisa (IT), Pisa, Italy.
- Neurol. Sci. 2013 Oct 1;34(10):1871-3.
AbstractAcute basilar artery occlusion has a poor prognosis and best treatment has not been assessed yet; as for intra-arterial treatment, no "gold standard" exists. We evaluated a series of ten patients treated with intra-arterial combination of recombinant tissue plasminogen activator (rtPA) and abciximab. Partial/complete recanalisation was achieved in all patients and good outcome (1 month Modified Rankin Scale 0-2) in eight cases, while one patient had symptomatic intracranial haemorrhage and died. Such outcome appears significantly better if compared with the results of Basilar Artery International Cooperation Study, suggesting that intra-arterial administration of rtPA and abciximab may be a promising option in patients with acute basilar artery occlusion undergoing endovascular treatment.
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