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Review
The beneficial role of SIRT1 in preventive or therapeutic options of Neurodegenerative Diseases.
- Haihui Liu, Si Xu, Chen Wang, Yu Deng, Bin Xu, Tianyao Yang, Jingyi Sun, and Wei Liu.
- Department of Environmental Health, School of Public Health, China Medical University, PR China.
- Neuroscience. 2022 Nov 10; 504: 799279-92.
AbstractSirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modify the gene expression through histone deacetylation. SIRT1 plays a crucial role in regulating a wide range of physiological processes by adjustment multiple mechanisms through the deacetylation of multiple substrates. Neurodegenerative diseases are a series of chronic diseases characterized by dysfunction and loss of neurons. Its basic pathogenesis is filamentous tangles and amyloid deposits, such as Amyloid-β (Aβ), tau protein, α-synuclein, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). This summarizes introduces the structure and function of SIRT1, and then analyzes the protective effects of SIRT1 on neurological diseases by regulating circadian rhythm, aging, oxidative stress, mitochondrial dysfunction and neuroinflammation related pathways.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
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