• J Coll Physicians Surg Pak · Oct 2022

    Evaluation of Calciferol, Cobalamin, and Stromelysin-1 in Patients with Diabetic Peripheral Neuropathy due to Type-2 Diabetes Mellitus.

    • Bulent Bilir, Ibrahim Yilmaz, Numan Karaarsalan, Betul Ekiz Bilir, Necati Kaplan, and Hanefi Ozbek.
    • Department of Internal Medicine, Namik Kemal University School of Medicine, Tekirdag, Turkey.
    • J Coll Physicians Surg Pak. 2022 Oct 1; 32 (10): 125512591255-1259.

    ObjectiveTo evaluate the relationship between calciferol (vitamin D), cobalamin (vitamin-B12), and Stromelysin-1 (MMP-3) circulating levels in patients with diabetic peripheral neuropathy (DPN), patients with DM type 2 (T2DM) without neuropathy, and healthy control groups.Study DesignCross-sectional descriptive study.Place And Duration Of StudyDepartment of Internal Medicine, Namik Kemal University of Medicine, Tekirdag, Turkey, between November 2020 and February 2022.MethodologyHealthy, age, and gender matched volunteers who were admitted to the hospital for a check-up with no health problem constituted the control group (n=30). Cases diagnosed with T2DM (n=30) and those with DPN (n=30) comprised the experimental group. Stromelysin-1, calciferol, and cobalamin levels were analysed from blood samples from all groups using enzyme-linked immunosorbent assay (ELISA) with a commercial kit. Tukey's Honest Significant Difference (HSD) test was performed after one-way analysis of variance (ANOVA) for intergroup comparisons. Alpha significance level was accepted as.

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