• J Coll Physicians Surg Pak · Oct 2022

    Cancer: Can CRISPR Become a Game Changer?

    • Sikandar Hayat Khan.
    • Department of Pathology, PNS Hafeez Naval Hospital, Islamabad, Pakistan.
    • J Coll Physicians Surg Pak. 2022 Oct 1; 32 (10): 1339-1340.

    AbstractRecent development in CRISPR technologies has emerged as a powerful tool for genome editing, which can become a powerful diagnostic and therapeutic option for cancer patients. While literature search demonstrates some successes in this dimension in animal models and phase-I human trials, still the promised panacea has shortcomings in terms of off-target mutations (OTMs), minimal efficiency, and tailoring individualised interventions. While there is a promise for the future, although the CRISPR technology still has to climb up the ladder in terms of improvements with more enhanced efficiency tools for delivering the payload into cell and reducing the off-target mutations. Key Words: CRISPR, Oncology, Off-target mutations (OTMs), Genome editing, 3-D cell cultures.

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