• Neuroscience · Nov 2022

    Review

    The Role of Vesicle Release and Synaptic Transmission in Depression.

    • Cheng-Cheng Zhang, Li-Xia Zhu, Hu-Jiang Shi, and Li-Juan Zhu.
    • Key Laboratory of Developmental Genes and Human Diseases, MOE, Department of Histology and Embryology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, PR China.
    • Neuroscience. 2022 Nov 21; 505: 171185171-185.

    AbstractDepressive disorder is the leading cause of disability worldwide, yet the mechanisms underlying depression are not fully understood. Vesicle release is essential for synaptic neurotransmission, the abnormalities of vesicle release and synaptic plasticity are associated with various neuropsychiatric disorders. Neural circuits are ensembles of interconnected neurons that collectively perform specific functions. To some extent, depression may be caused by a disruption in the structural and functional connections of the neural circuits underlying emotion regulation. In this review, we summarized the role of abnormalities of vesicle release and synaptic transmission, as well as the related regulatory molecules and signal pathways in the regulation of depression.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

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