• J Coll Physicians Surg Pak · Aug 2022

    Case Reports

    Primary Hepatic Sarcomatoid Carcinoma Presenting with Dysphagia: A Rare Presentation.

    • Khadim Hussain Samejo, Rajesh Mandhwani, Zain Majid, Muhammed Mubarak, and Nasir Hassan Luck.
    • Department of Gastroenterology, Sindh Institute of Urology and Transplantation, SIUT, Karachi, Pakistan.
    • J Coll Physicians Surg Pak. 2022 Aug 1; 32 (8): S159-S161.

    AbstractA 50-year male presented with vomiting and dysphagia for 2 weeks. Laboratory workup showed a positive serology for hepatitis C and normal serum α-fetoprotein (AFP) levels. CT abdomen revealed a large lesion in the right lobe of the liver extending upto the lower esophagus causing significant luminal narrowing and dysphagia. The enhancement pattern on the CT scan was not consistent with hepatocellular carcinoma. Liver lesion biopsy showed an infiltrating spindle cell lesion exhibiting fascicles of spindle cells with moderately hyperchromatic nuclei and perinuclear vacuolization. Mitotic count was 2-3/10 HPFs. Immunohistochemical markers were positive for CK AE1/AE3 and vimentin. Thus, a diagnosis of sarcomatoid carcinoma was made on the basis of morphological and immunohistochemical features. Due to unresectable disease and poor functional status, palliative care was opted for. Key Words: Dysphagia, Vomiting, Liver biopsy, Sarcomatoid carcinoma.

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