• Katarina Kneppova, Ivana Kralikova, Marek Cambal, and Peter Labas.
• Bratisl Med J. 2022 Jan 1; 123 (11): 806-812.

ObjectiveThe purpose of the study was to follow up the cortisol levels in relation to the postoperative pain intensity, its levels after treatment with opiate and non-opiate analgesics, and to monitor the relationship between the blood glucose and cortisol levels. Another goal was to optimize the postoperative analgesia of geriatric patients with the known combinations of analgesics.MethodsThe cohort comprised 28 geriatric patients undergoing laparoscopic cholecystectomy. The patients were divided according to the intensity of postoperative pain into the groups with opiate and non-opiate analgesia. Furthermore, they were divided according to their physical condition (ASA classification) into two groups, ASA 2 and ASA 3. We evaluated three values ​​of blood glucose levels, on the day before surgery, on the operative and the first postoperative days and those of cortisol on the day of surgery.ResultsThe patients had the blood glucose levels without significant deviation during the three days of measurements. The cortisol levels increased with the intensity of postoperative pain. High levels of cortisol were observed not only in the patients, who experienced acute pain after non-optimal postoperative analgesia, but also in those treated with strong opiates in the immediate postoperative period. The patients with mild pain intensity, treated with a combination of non-opiate analgesics, had the lowest values. The role of the patient's gender in both blood glucose and cortisol levels was not observed.ConclusionThe cortisol levels have not corresponded so much with the assessment of acute postoperative pain as with the stress that was evoked in the patient due to hospitalization and fear of surgery. It is crucial to eliminate as much as possible all the stressors that can affect the cortisol levels and thus the blood glucose levels (Fig. 6, Ref. 25).

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