• Bratisl Med J · Jan 2022

    The relationship between ghrelin and inflammation in diabetic rat stomach.

    • Bilge Nur Bilge and Sema Bolkent.
    • Bratisl Med J. 2022 Jan 1; 123 (11): 822-827.

    BackgroundGhrelin is a hormone that regulates the digestive system, as well as has immunomodulating effects. The aim of this study is to explain effects of ghrelin on inflammation and oxidative stress parameters in the stomach.MethodsMale Sprague Dawley rats 8-10 weeks old (n = 21) were randomly divided into three groups as control, type 2 diabetes (T2DM) and diabetes and given exogenous ghrelin (T2DM+Gh). The daily feed and water intake of the animals were measured. The levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), and interleukin-10 (IL-10) mRNA in tissues were analyzed using RT-PCR technique. Ghrelin and nuclear factor-κβ (NF-κβ) peptides were detected by immunohistochemistry.ResultsT2DM group had a significant increase in water intake when compared to control group. T2DM group had significantly higher levels of IL-6, IL-1, and IL-10 mRNA expression than control group. IL-1β and IL-10 mRNA expression were significantly lower in T2DM+Gh group than in T2DM group. In T2DM group, NF-κβ was higher than in control group, but it was lower in T2DM+Gh group. In terms of oxidative stress, there were non-significant changes.ConclusionAccording to our findings, exogenous ghrelin intake was found to be highly effective in reducing inflammation in stomach tissue with type 2 diabetes (Tab. 1, Fig. 3, Ref. 33). Text in PDF www.elis.sk Keywords: ghrelin, rat, type 2 diabetes, stomach, inflammation.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…