• Chaolin Teng, Mengwei Wang, Wei Wang, Jin Ma, Min Jia, Min Wu, Yuanyuan Luo, Yu Wang, Yiyang Zhang, and Jin Xu.
• The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, PR China; The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi 710049, PR China; Department of Aerospace Medicine, The Air Force Medical University, Xi'an, Shaanxi 710068, PR China.
• Neuroscience. 2022 Dec 1; 506: 809080-90.

AbstractStudies of scalp electroencephalography (EEG) had shown altered topological organization of functional brain networks in patients with major depressive disorder (MDD). However, most previous EEG-based network analyses were performed at sensor level, while the interpretation of obtained results was not straightforward due to volume conduction effect. To reduce the impact of this defect, the whole cortical functional brain networks of MDD patients were studied during resting state based on EEG-source estimates in this paper. First, scalp EEG signals were recorded from 19 patients with MDD and 20 normal controls under resting eyes-closed state, and cortical neural signals were estimated by using sLORETA method. Then, the correntropy coefficient of wavelet packet coefficients was performed to calculate functional connectivity (FC) matrices in four different frequency bands: δ, θ, α, β, respectively. Afterwards, topological properties of brain networks were analyzed by graph theory approaches. The results showed that the global FC strength of MDD patients was significantly higher than that of healthy subjects in α band. Also, it was found that MDD patients have abnormally increased clustering coefficient and local efficiency in both α and β bands compared to normal people. Furthermore, patients with MDD exhibited increased nodal clustering coefficients in the left lingual gryus and left precuneus in α band. In addition, β band global clustering coefficient was positively correlated with the scores of depression severity. Therefore, the findings indicated the cortical functional brain networks in MDD patients were disruptions, which suggested it would be one of potential causes of depression.Copyright © 2022. Published by Elsevier Ltd.

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