• Curr Med Res Opin · Dec 2022

    Review

    Cell therapies for acute and chronic traumatic brain injury.

    • Masahito Kawabori, Dai Chida, Bijan Nejadnik, Anthony H Stonehouse, and David O Okonkwo.
    • Department of Neurosurgery, Hokkaido University Hospital, Sapporo, Japan.
    • Curr Med Res Opin. 2022 Dec 1; 38 (12): 218321892183-2189.

    AbstractTraumatic brain injury (TBI) is a global health problem, for which there are no approved therapies. Advances in acute clinical care have improved post-TBI survival, yet many patients are left with chronic TBI-related disabilities (i.e. chronic TBI). Existing treatments that focus on rehabilitation and symptom management do not modify the disease and have limited effectiveness. Consequently, chronic TBI-related disabilities remain a significant unmet medical need. Cell therapies have neuroprotective and neurorestorative effects which are believed to modify the disease. In this article, we review the safety and efficacy of cell therapies in early-phase clinical studies that have shown potential to improve outcomes in acute to chronic phases of TBI.

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