• J. Neurophysiol. · Jul 2009

    Heat-induced action potential discharges in nociceptive primary sensory neurons of rats.

    • Wolfgang Greffrath, Stefan T Schwarz, Dietrich Büsselberg, and Rolf-Detlef Treede.
    • Division of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim, CBTM Ludolf-Krehl-Strasse 13-17, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, D-68167 Mannheim, Germany. wolfgang.greffrath@medma.uni-heidelberg.de
    • J. Neurophysiol. 2009 Jul 1;102(1):424-36.

    AbstractAlthough several transducer molecules for noxious stimuli have been identified, little is known about the transformation of the resulting generator currents into action potentials (APs). Therefore we investigated the transformation process for stepped noxious heat stimuli (42-47 degrees C, 3-s duration) into membrane potential changes and subsequent AP discharges using the somata of acutely dissociated small dorsal root ganglion (DRG) neurons (diameter

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