• Jehad A Aldali, Fahad T Alotaibi, Glowi A Alasiri, Renad A Almesned, Aroob M Alromih, Afnan M Almohandes, and Shahad F Alsenidi.
• From the Department of Pathology (Aldali), from the Department of Physiology, College of Medicine (Alotaibi), from the Department of Biochemistry (Alasiri), and from the College of Medicine (Almesned, Alromih, Almohandes, Alsenidi), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
• Saudi Med J. 2022 Nov 1; 43 (11): 124812531248-1253.

ObjectivesTo investigate the side effects of Pizer- BioNTech mRNA (BNT162b2) and Spikevax (mRNA- 1273) Coronavirus disease 2019 (COVID-19) vaccines on adolescents in Riyadh, Saudi Arabia.MethodsA cross-sectional study using an online questionnaire was carried out among COVID-19 vaccine adolescent recipients in Riyadh, Saudi Arabia. After receiving at least one dose of each vaccine, general and demographic data were collected, and vaccine-related side effects were evaluated.ResultsThe final sample consisted of 604 participants with a majority age group of 16-17 years old. Approximately 89.1% of the study participants were female. Most participants reported pain at the injection site (85.1% 1st dose, 79.8% 2nd dose), feeling tired, and headache (58.6% 1st dose, 64.2% 2nd dose). Moreover, we found that patients who took the first dose and had a chronic disease had 2.4 times higher odds of having menstrual disorder (females) than non-chronic disease patients (p=0.03) and 4.5 times higher odds of exhibiting breathing congestion (p=0.01). In addition, patients with chronic disease had 2.4 times higher odds of exhibiting muscle and joint pain and dizziness than non-chronic disease patients (p=0.01, p=0.02). Males were less likely to have dizziness after the first dose than females (OR=0.26, p=0.01).ConclusionThis study investigates the adverse effects of COVID-19 vaccines among adolescents in Riyadh. As a result, this study creates a database to inform people about the risk of experiencing side effects based on their gender, age, and the vaccine type; more investigation is needed to better understand the link between risk factors and the development of adverse effects.Copyright: © Saudi Medical Journal.

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