• Huiming Hou, Ming Zhou, Xing Zhou, Wenxuan Guo, Rujie Zhuang, Hong Yin, and Jinlei Li.
• Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang City, China.
• Medicine (Baltimore). 2022 Nov 11; 101 (45): e31926e31926.

BackgroundAnkle sprains occur very frequently in daily life, but people who do not pay attention to them and do not receive proper diagnosis and treatment are very prone to develop chronic ankle lateral instability (CALI) at a later stage. For CALI where conservative treatment has failed, reconstruction of the lateral collateral ligament of the ankle can achieve satisfactory results, but there are various and controversial ways of ligament reconstruction. While percutaneous reconstruction of ankle lateral ligament (PLCLR) needs to be performed repeatedly under fluoroscopy, total arthroscopic reconstruction of ankle lateral ligament (ALCLR) is increasingly recognized by experts and scholars for its minimally invasive and precise characteristics, and has achieved good clinical results. Therefore, it is imperative that a meta-analysis be performed to provide evidence as to whether there is a difference between ALCLR and PLCLR in the treatment of CALI.MethodsWe will search articles in 7 electronic databases including Chinese National Knowledge Infrastructure, Wanfang Data, Chinese Scientific Journals Database, Chinese databases SinoMed, PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction of language and status, the time from the establishment of the database to September 2022.We will apply the risk-of-bias tool of the Cochrane Collaboration for Randomized Controlled Trials to assess the methodological quality. Risk-of-Bias Assessment Tool for Non-randomized Studies was used to evaluate the quality of comparative studies. Statistical analysis will be conducted using RevMan 5.4 software.ResultsThis systematic review will evaluate the functional outcomes and radiographic results of ALCLR in the treatment of CALI.ConclusionThe conclusion of this study will provide evidence for judging whether ALCLR is superior to PLCLR for treatment of CALI.Trial Registration NumberCRD42022362045.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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