• Jihong Yu, Haifen Ma, Ji He, Min Wang, Bo Yu, Shaonan Ge, and Zhibo Dai.
• Beilun People's Hospital, Beilun Branch of The First Affiliated Hospital, School of Medicine, Zhejiang University, Ningbo, Zhejiang, People's Republic of China.
• Medicine (Baltimore). 2022 Nov 18; 101 (46): e31849e31849.

AbstractATP-binding-cassette subfamily E member 1 (ABCE1) has been identified as an essential component of RNA translation and cell proliferation. However, studies on its role in pan-cancer are limited. Here, we aimed to characterize ABCE1 expression and its potential biological functions in cancer. ABCE1 expression was analyzed using RNA-seq data from The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx) database, and the Clinical Proteomic Tumor Analysis Consortium database. The prognostic value of ABCE1 was analyzed using clinical survival data from TCGA. We downloaded the immune cell infiltration score of TCGA samples from published articles and online databases and performed a correlation analysis between immune cell infiltration levels, chemokines/chemokine receptors, and ABCE1 expression. We further assessed the association between ABCE1-correlated genes and their functions in pancreatic adenocarcinoma (PAAD). In general, ABCE1 gene expression was upregulated in most tumors. There were significant strong correlations between ABCE1 expression and tumor-infiltrating cells in cancers. Furthermore, RNA transport and ribosome biogenesis were significantly related to ABCE1 expression in PAAD. Our study revealed that ABCE1 may serve as a potential prognostic and immunological pan-cancer biomarker. Moreover, ABCE1 may be used in the development of a novel target for PAAD.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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