• Medicine · Nov 2022

    The efficacy and safety of radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer: A protocol for systematic review and meta-analysis.

    • Lei Zhang, Jianfeng Li, and Chenle Jia.
    • Department of Head and Neck Surgery Ward 1, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
    • Medicine (Baltimore). 2022 Nov 18; 101 (46): e31899e31899.

    BackgroundThe appropriate use of surgery or chemoradiotherapy-based approaches for organ preservation has been the subject of much debate. Unfortunately, there has been a lack of improvement in overall survival for patients with laryngeal carcinoma. In this study, we performed a protocol for systematic review and meta-analysis to evaluate the efficacy and safety radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer.MethodsThis protocol is reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. We will search the PubMed, Cochrane Library, EMBASE, and Web of Science databases from the inception dates to October, 2022, using the keywords "laryngeal cancer," "radiotherapy", and "chemotherapy." Cochrane "bias risk" tool is used to assess the bias risk of the quality of the included literature. All calculations were carried out with RevMan V.5.3 software.ResultsThe results of this study will provide evidence for judging whether radiotherapy combined chemotherapy is superior to surgery for treatment of advanced laryngeal cancer.ConclusionThis review will provide directions and recommendations for future research and clinical practices of radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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