• Xiayimaierdan Yibulayin, Keming Xu, Waresijiang Yibulayin, Abulimiti Abulaiti, Zhenhua Wu, Dan He, Anpeng Ran, Lei Ma, and Xiaohong Sun.
• Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.
• Medicine (Baltimore). 2022 Nov 18; 101 (46): e31619e31619.

RationaleIt is often difficult to perform transthoracic esophagectomy (TTE) in patients with chest deformities, as these patients may be lost to surgery for non-oncological reasons.Patient ConcernsIn this case, we had a patient with esophageal squamous cell carcinoma (ESCC) who was not suitable for TTE because of extensive thoracic adhesions caused by the left pneumonectomy 8 years ago.DiagnosesESCC.InterventionsBased on Professor Fujiwara's surgical method, we further improved it by proposing a single-port inflatable mediastinoscopy combined with laparoscopic-assisted esophagectomy.OutcomesAt the time of this writing, computed tomography and gastroscopy revealed no stenosis of anastomosis, and no evidence of disease recurrence.LessonsTo the best of our knowledge, the present case is the first single-port inflatable mediastinoscopic esophagectomy performed on a patient undergoing pneumonectomy.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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