• Mayra Costanti Vilela Campos, Silvana Simoes Velloso Schuler, Pamella de Barros Motta, Adriana Cátia Mazzoni, Francine Cristina da Silva, Domingues MartinsManoelaMOral Pathology and Oral Medicine, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Porta Santos FernandesKristianneKBioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil., Agnelli Mesquita-FerrariRaquelRBioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil., Ratto Tempestini HorlianaAnna CarolinaACBioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil., Kalil BussadoriSandraSBioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil., and Jansiski MottaLaraLBioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil..
• BioPhotonics Applied to Health Sciences Department, UNINOVE, São Paulo, Brazil.
• Medicine (Baltimore). 2022 Nov 18; 101 (46): e31218e31218.

IntroductionOrofacial pain and tensional cephalea were symptoms commonly reported in COVID-19 patients, even after recovery, and were considered chronic pain in these cases. The aim of this research is to evaluate the effect of the application of photobiomodulation with red and infrared lasers applied locally and systemically.Methods And AnalysisFor this purpose, individuals who have been diagnosed with COVID-19 and have had a tension headache and/or orofacial pain for more than 3 months will be selected by convenience. The participants will be divided into two different groups: G1-photobiomodulation with red and infrared laser with local application on the pain points (808 nm and 660 nm, 100 mW, 6 J per point) and G2-photobiomodulation with red laser with transcutaneous application on the radial artery (660 nm, 100 mW, 30 minutes). All participants will be treated for a period of 4 weeks, with 8 application sessions. The effects will be measured by means of blood lactate level, Brief Pain Inventory, Visual Analog Scale (VAS), and Cephalea Impact Test. The data will be collected weekly before and after the treatment, and the following tests will be applied: Analysis of variance (ANOVA), Tukey paired t test, Kruskal-Wallis, or Wilcoxon, according to data distribution. α = 0.05 will be considered as the level of statistical significance.Ethics And DisseminationThis study was approved by the Research Projects Committee of the Nove de Julho University (approval number 4.673.963). Results will be disseminated through peer-reviewed journals and events for the scientific and clinical community, and the general public. It is registered in the ClinicalTrials.gov database with the number NCT05430776.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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