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Case Reports
A case report of small cell ovarian neuroendocrine carcinoma combined with immunochemotherapy.
- Yuan-Xue Zhu, Xiang-Peng Gao, Lei Xin, and You-Chao Jia.
- Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei, P.R. China.
- Medicine (Baltimore). 2022 Nov 18; 101 (46): e31445e31445.
BackgroundSmall cell ovarian neuroendocrine (NE) carcinoma is a rare NE tumor with a low incidence, poor prognosis, and no standardized treatment. To date, there have been no clear reports on the efficacy or prognosis of combined immunological and chemotherapy-based approaches in patients with this type of tumor.MethodsWe administered the immune checkpoint inhibitor tirelizumab (PD-1 mab), in combination with etoposide and cisplatin chemotherapy (EP), to a patient with small cell ovarian NE carcinoma to examine its efficacy and safety.ResultsThe evaluation of efficacy was PR for every 2 courses of application, and immunomaintenance therapy was administered after 6 courses of treatment.ConclusionOur studies indicate that tirelizumab combined with EP, may be an effective treatment for small cell ovarian NE carcinoma.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
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