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- Nayomi Camilus, Carlos Quintero Arias, and Sanela Martic.
- Department of Forensic Science, Environmental and Life Sciences, Trent University, ON, Canada.
- Neuroscience. 2023 Feb 10; 511: 110130110-130.
AbstractNuclear TAR DNA-binding protein 43 (TDP-43) mitigates cellular function, but the dynamic nucleus-cytoplasm shuttling of TDP-43 is disrupted in diseases, such as Amyotrophic Lateral Sclerosis (ALS). The polymorphic nature of the TDP-43 structures in vitro and in vivo is a result of environmental factors leading to the protein pathogenesis. Once the triggers which mitigate TDP-43 biochemistry are identified, new therapies can be developed. This review aims to illustrate recent discoveries in the diversity of TDP-43 structures (amyloidogenic and non-amyloidogenic) and highlight the triggers which result in their formation.Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
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