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- Angelika E Charkiewicz, Marzena Garley, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Wojciech Miltyk, Joanna Motyka, and Wioleta J Omeljaniuk.
- Department of Public Health Medical, University of Bialystok, Bialystok, Poland.
- Arch Med Sci. 2022 Jan 1; 18 (6): 166616711666-1671.
IntroductionThe present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies.MethodsWe present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease.ResultsElevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2.ConclusionsPCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.Copyright: © 2022 Termedia & Banach.
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