• Shan Wang, Tengfei Li, Yuan Wang, Mengdi Wang, Yibin Liu, Xiaoguang Zhang, and Lijuan Zhang.
• Departments of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
• Medicine (Baltimore). 2022 Nov 25; 101 (47): e31678e31678.

Rationale5-Fluorouracil (5-FU) and actinomycin D (ActD) are often used in chemotherapy for various cancers. Side effects are more common in bone marrow suppression, liver function impairment, and gastrointestinal responses. Skin effects are rare and easy to be ignored by doctors and patients, which can lead to life-threatening consequence.Patient ConcernsWe reported a 45-year-old woman patient developed skin erythema and fingernail belt in chemotherapy of 5-FU and ActD.DiagnosisErythema multiforme drug eruption.InterventionsLaboratory tests including blood and urine routine, liver and kidney function, electrolytes and coagulation function and close observation.OutcomesThe rash was gone and the nail change returned.LessonsDelays in diagnosis or treatment may lead to serious consequence. We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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