• Yu Xiao, Shanshan Peng, Tianyi Mao, Xiangjun Li, Wenzheng Ye, and Muping Fang.
• The Central Hospital of Xiaogan, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Hubei, China.
• Medicine (Baltimore). 2022 Nov 25; 101 (47): e32074e32074.

RationalePorokeratosis ptychotropica represents an unusual form of porokeratosis characterized by symmetrical dyskeratotic skin lesions on the gluteal clefts. Herein, we report a case of porokeratosis ptychotropica.Patient ConcernsA 33-year-old man, who complained of itching papules and plaques in the gluteal cleft and the buttocks for the last 7 years. Clinical examination showed a large well-defined reddish brown verrucous plaque located on both buttocks along with satellite papules on the inner thigh. Dermoscopy and histopathological findings were consistent with porokeratosis.DiagnosisHe was diagnosed with porokeratosis ptychotropica.OutcomesNo significant improvement was observed following treatment with oral acitretin and a topical retinoid.LessonsThe case report highlights the need for awareness amongst dermatologists for porokeratosis ptychotropica as a differential diagnosis for pruritic papules in the gluteal fold.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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