• Bo Zheng, Fang Fang Wu, Xiao Xiao Li, Ren Shen, Zong Zheng, and Hong Yan Liu.
• Yuhuan People's Hospital, Taizhou, China.
• Medicine (Baltimore). 2022 Nov 25; 101 (47): e31776e31776.

BackgroundThis study aimed to assess the diagnostic accuracy of polymerase-chain-reaction by saliva.MethodWe searched Pubmed, EMBASE, Cochrane Library and Web of Science. A case-control or cohort study designed to explore the saliva specimens for diagnosing the cytomegalovirus infection was eligible for this study. Sensitivity (SEN), specificity (SPE), diagnostic odds ratio (DOR), and summary receiver operating characteristic curves were calculated.ResultsNine articles were selected for the meta-analysis. For assessing saliva PCR with urine culture, the SEN, SPE, and DOR were 0.97 [95% confidential interval (CI):0.61,1.00] 1.00 [95%CI:0.99, 1.00] 15672 [95%CI:558, 440325], respectively; for assessing saliva PCR with urine PCR, the SEN, SPE, and DOR were 0.87 [95%CI:0.79, 0.92] 1.00 [95%CI:1.00, 1.00] 15637 [95%CI:5946, 41126], respectively; for total assessment, the SEN, SPE, and DOR were0.91 [95%CI:0.70, 0.98] 1.00 [95%CI:1.00, 1.00] 8493 [95%CI:1429, 50487], respectively.ConclusionWe reported that saliva PCR performed well in the diagnosis of cytomegalovirus infection.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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