• Nobumasa Ohara, Masanori Kaneko, Toshio Yano, Naoko Sato, Hiroyuki Usuda, Masashi Miyakoshi, Tatsuo Furukawa, Tadashi Koike, Kenzo Kaneko, and Kyuzi Kamoi.
• Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
• Intern. Med. 2015 Jan 1; 54 (18): 236123652361-5.

AbstractWe herein report the case of a 66-year-old Japanese man with acute-onset type 1 diabetes mellitus (T1D) accompanied by pernicious anemia. After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related autoantibodies and began insulin therapy in 2001. Eight years later, he developed gastric autoantibody-positive pernicious anemia and began methylcobalamin treatment. Previous studies have reported cases of slowly progressive autoimmune T1D concomitant with pernicious anemia. The present case suggests that potential associations with organ-specific autoimmune disorders should be considered during the long-term follow-up of T1D patients, even though verifiable islet-related autoantibodies are undetectable.

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