Efficacy of fluoxetine in Austrian patients with

Wien. Klin. Wochenschr. · Jun 1999

Randomized Controlled Trial Comparative Study Clinical Trial

Efficacy of fluoxetine in Austrian patients with obsessive-compulsive disorder.

In an 8-week double-blind placebo-controlled trial we studied the efficacy of fluoxetine (FLX) in 53 Austrian patients with obsessive compulsive disorder (OCD) diagnosed according to DSM-III-R. The dosage of FLX was fixed at either 20, 40, or 60 mg per day. ⋯ Patients treated with at least 40 mg FLX per day showed significantly higher response rates than did those receiving either placebo or FLX 20 mg/day. Compulsions were more reduced than obsessions and we also observed a strong placebo effect which is largely attributable to an improvement in the Y-BOCS compulsion subscore.

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- W Zitterl, K Meszaros, K Hornik, T Twaroch, M Dossenbach, K Zitterl-Eglseer, and H G Zapotoczky.
- Universitätsklinik für Psychiatrie Wien, Austria.
- Wien. Klin. Wochenschr. 1999 Jun 4; 111 (11): 439442439-42.
AbstractIn an 8-week double-blind placebo-controlled trial we studied the efficacy of fluoxetine (FLX) in 53 Austrian patients with obsessive compulsive disorder (OCD) diagnosed according to DSM-III-R. The dosage of FLX was fixed at either 20, 40, or 60 mg per day. Response was prospectively defined as an at least 25% reduction on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and an improvement on Clinical Global Impression (CGI) rating to at least "much improved" at the endpoint. Patients treated with at least 40 mg FLX per day showed significantly higher response rates than did those receiving either placebo or FLX 20 mg/day. Compulsions were more reduced than obsessions and we also observed a strong placebo effect which is largely attributable to an improvement in the Y-BOCS compulsion subscore.

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Efficacy of fluoxetine in Austrian patients with obsessive-compulsive disorder.

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