Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Jun 1999
Randomized Controlled Trial Comparative Study Clinical TrialEfficacy of fluoxetine in Austrian patients with obsessive-compulsive disorder.
In an 8-week double-blind placebo-controlled trial we studied the efficacy of fluoxetine (FLX) in 53 Austrian patients with obsessive compulsive disorder (OCD) diagnosed according to DSM-III-R. The dosage of FLX was fixed at either 20, 40, or 60 mg per day. ⋯ Patients treated with at least 40 mg FLX per day showed significantly higher response rates than did those receiving either placebo or FLX 20 mg/day. Compulsions were more reduced than obsessions and we also observed a strong placebo effect which is largely attributable to an improvement in the Y-BOCS compulsion subscore.