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- Takao Watanabe, Masanori Abe, Fujimasa Tada, Kanako Aritomo, Hironori Ochi, Yohei Koizumi, Yoshio Tokumoto, Masashi Hirooka, Teru Kumagi, Yoshio Ikeda, Bunzo Matsuura, and Yoichi Hiasa.
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.
- Intern. Med. 2015 Jan 1; 54 (4): 395399395-9.
AbstractA 36-year-old Japanese woman took over-the-counter (OTC) medication for headaches for 20 days. Subsequently, five days after discontinuing the medication, a skin rash developed over the patient's upper and lower limbs and face, in addition to a fever, brown urine and serious liver dysfunction. Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made. The patient's symptoms and liver function tests returned to normal following treatment with systemic steroids.
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