• Jan D Wandrey, Mina Kandić, Linus Haberbosch, and Angela Serian.
• Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Charité Mitte und Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Gliedkörperschaft der Freien Universität Berlin, der Humboldt Universität zu Berlin und des Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Deutschland.
• Schmerz. 2023 Aug 1; 37 (4): 281289281-289.

BackgroundChronic pain is a common health problem, for which the treatment is complex and challenging. Non-invasive brain stimulation techniques, specifically transcranial alternating current stimulation (tACS), show promise as a well-tolerated new therapeutic modality with few side effects. This is supported by growing evidence of an association between altered neuronal oscillations and chronic pain. However, to date, only a handful of studies with variable methodology have evaluated tACS for potential applicability to patients with chronic pain.ObjectivesPresentation and discussion of the evidence thus far, evaluation of a potential therapeutic benefit for chronic pain patients.Materials And MethodsLiterature search in MEDLINE, Embase, Cochrane Library, and Google Scholar databases.ResultsTo date, tACS for chronic pain therapy has been investigated in only three studies with very different methodological approaches and quality.DiscussionThese data currently do not provide sufficient evidence for the therapeutic use of tACS for chronic pain therapy. Future studies may address the question of a therapeutic benefit of tACS for this indication utilizing improved stimulation techniques and considering existing recommendations for the design and conduct of tACS studies.© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

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