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B Acad Nat Med Paris · Mar 2007
Review Comparative Study[Intraepithelial lesions and neoplasia associated with human papillomavirus infection].
- Didier Riethmuller, Jean-Sébastien Guerrini, and François Aubin.
- EA 3181, IFR 133, Université de Franche-Comté, Service de Gynécologie-Obstétrique, Hôpital St Jacques, CHU Besançon, Pavillon La mère et l'enfant, 25030 Besançon Cedex.
- B Acad Nat Med Paris. 2007 Mar 1; 191 (3): 601609601-9; discussion 609.
AbstractAnogenital lesions induced by human papillomaviruses (HPV) are due to both high-risk HPV types involved in carcinogenesis of the cervix (and also, to a lesser extent, of the vulva, anus and vagina) and to low-risk HPV types that cause external genital warts in the perianal region, perineum, vulva and vagina (less often the cervix). Cervical cancer is thus virus-induced, and there is a continuum from intraepithelial lesions to invasive cancer. This offers the opportunity to screen cervical smears for cytological abnormalities or to detect high-risk HPV infection by molecular methods. Although the causal link between human genital papillomavirus infection and cervical neoplasia is well established, the role of beta-HPV in non melanoma skin cancers is unclear.
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