• Bradley M Ritland, William H Neumeier, Sam H Jiang, Carl D Smith, Kristin J Heaton, Audrey M Hildebrandt, Muhammad A Jabbar, Hui Jun Liao, Eduardo Coello, Wufan Zhao, Camden P Bay, and Alexander P Lin.
• Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
• J Neuroimaging. 2023 Mar 1; 33 (2): 279288279-288.

Background And PurposeThe purpose was to explore the effects of transcutaneous trigeminal nerve stimulation (TNS) on neurochemical concentrations (brainstem, anterior cingulate cortex [ACC], dorsolateral prefrontal cortex [DLPFC], ventromedial prefrontal cortex [VMPFC], and the posterior cingulate cortex [PCC]) using ultrahigh-field magnetic resonance spectroscopy.MethodsThis double-blinded study tested 32 healthy males (age: 25.4 ± 7.3 years) on two separate occasions where participants received either a 20-minute TNS or sham session. Participants were scanned at baseline and twice post-TNS/sham administration.ResultsThere were no group differences in concentration changes of glutamate, gamma-aminobutyric acid, glutamine, myoinositol (mI), total N-acetylaspartate, total creatine (tCr), and total choline between the baseline scan and the first post-TNS/sham scan and between the first and second post-TNS/sham scan in the brainstem, ACC, DLPFC, VMPFC, and PCC. Between the baseline scan and the second post-TNS/sham scan, changes in tCr (mean difference = 0.280 mM [0.075 to 0.485], p = .026) and mI (mean difference = 0.662 mM [0.203 to 1.122], p = .026) in the DLPFC differed between groups. Post hoc analyses indicated that there was a decrease in tCr (mean change = -0.201 mM [-0.335 to -0.067], p = .003) and no change in mI (mean change = -0.327 mM [-0.737 to 0.083], p = .118) in the TNS group; conversely, there was no change in tCr (mean change = -0.100 mM [-0.074 to 0.274], p = .259) and an increase in mI (mean change = 0.347 mM [0.106 to 0.588], p = .005) in the sham group.ConclusionThese data demonstrate that a single session of unilateral TNS slightly decreased tCr concentrations in the DLPFC region.© 2022 American Society of Neuroimaging. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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